ABSTRACT
Pulmonary hypertension is characterized by the progressive increase of pulmonary arterial pressure and the gradually increasing of pulmonary vascular resistance,leading to a common disease of right heart failure and death.The pathogenesis of pulmonary hypertension has not yet been fully elucidated.The pathological feature of pulmonary arterial hypertension is the pulmonary vascular remodeling including vascular endothelial cell injury,smooth muscle cell proliferation,migration and deposition of extracellular matrix.MicroRNA is an endogenous nucleotide fragment,which can activate the expression of genes related to signal transduction through the corresponding biological behavior.Recent studies have found that microRNA plays an important role in pulmonary arterial hypertension through the injury of vascular endothelial cells,smooth muscle cell proliferation,migration and extracellular matrixdeposition.The research about microRNA that participates in the mechanism of pulmonary arterial hypertension provides a new theoretical basis for the prevention and treatment of pulmonary arterial hypertension.This review focuses on progress of microRNA and the mechanisms of pulmonary arterial hypertension.